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Protein kinase C polymorphisms and vitamin D levels in multiple sclerosis
  1. Murali Ramanathan
  1. Correspondence to Professor Murali Ramanathan, State University of New York, Buffalo, 355 Kapoor Hall, Buffalo, NY 14214, USA; murali{at}buffalo.edu

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Epidemiological evidence suggests that low levels of serum vitamin D are a possible risk factor for the development of multiple sclerosis (MS).1 The exact mechanisms by which vitamin D exerts its effects on MS risk are not well understood. The paper by Lin et al2 identifies novel protein kinase C polymorphisms associated with 25 hydroxy vitamin D levels in MS patients.

Vitamin D is derived from the diet and from endogenous production in the skin. Vitamin D is akin to a pro-drug: it must be hydroxylated to the 25 hydroxy vitamin D metabolite in the liver and then to the active 1, 25 dihydroxy vitamin D form that binds the vitamin D receptor. Several cytochrome P450 enzymes including CYP2R1, CYP2D11 and CYP2D25 can catalyse the 25-hydroxylation reaction3 …

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