rss
J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2013-307485
  • Cerebrovascular disease
  • Research paper

Stress resilience in male adolescents and subsequent stroke risk: cohort study

Open Access
  1. Scott Montgomery2,3,6,7
  1. 1Department of Physiotherapy, Örebro University Hospital, Örebro, Sweden
  2. 2School of Health and Medical Sciences, Örebro University, Örebro, Sweden
  3. 3Department of Clinical Epidemiology and Biostatistics, Örebro University Hospital, Örebro, Sweden
  4. 4Centre for Health Care Sciences, Örebro County Council, Örebro, Sweden
  5. 5Department of Neurology, Örebro University Hospital, Örebro, Sweden
  6. 6Department of Epidemiology and Public Health, University College London, London, UK
  7. 7Cinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
  1. Correspondence to Cecilia Bergh, Department of Physiotherapy, Örebro University Hospital, Örebro 701 85, Sweden; cecilia.bergh{at}orebroll.se
  • Received 18 December 2013
  • Revised 14 February 2014
  • Accepted 4 March 2014
  • Published Online First 28 March 2014

Abstract

Objective Exposure to psychosocial stress has been identified as a possible stroke risk, but the role of stress resilience which may be relevant to chronic exposure is uncertain. We investigated the association of stress resilience in adolescence with subsequent stroke risk.

Methods Register-based cohort study. Some 237 879 males born between 1952 and 1956 were followed from 1987 to 2010 using information from Swedish registers. Cox regression estimated the association of stress resilience with stroke, after adjustment for established stroke risk factors.

Results Some 3411 diagnoses of first stroke were identified. Lowest stress resilience (21.8%) compared with the highest (23.7%) was associated with increased stroke risk, producing unadjusted HR (with 95% CIs) of 1.54 (1.40 to 1.70). The association attenuated slightly to 1.48 (1.34 to 1.63) after adjustment for markers of socioeconomic circumstances in childhood; and after further adjustment for markers of development and disease in adolescence (blood pressure, cognitive function and pre-existing cardiovascular disease) to 1.30 (1.18 to 1.45). The greatest reduction followed further adjustment for markers of physical fitness (BMI and physical working capacity) in adolescence to 1.16 (1.04 to 1.29). The results were consistent when stroke was subdivided into fatal, ischaemic and haemorrhagic, with higher magnitude associations for fatal rather than non-fatal, and for haemorrhagic rather than ischaemic stroke.

Conclusions Stress susceptibility and, therefore, psychosocial stress may be implicated in the aetiology of stroke. This association may be explained, in part, by poorer physical fitness. Effective prevention might focus on behaviour/lifestyle and psychosocial stress.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/