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The link between hyperoxia, delayed cerebral ischaemia and poor outcome after aneurysmal SAH: association or therapeutic endeavour
  1. Robert M Starke,
  2. Neal F Kassell
  1. Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
  1. Correspondence to Dr Robert M Starke, Department of Neurological Surgery, University of Virginia, P.O. Box 800212, Charlottesville, VA 22908, USA; rms6bx{at}hscmail.mcc.virginia.edu

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In this study, Jeon et al1 assess the association between exposure to hyperoxia in ventilated patients following aneurysmal subarachnoid haemorrhage (SAH) and both delayed cerebral ischaemia (DCI) and functional outcome. Prospective data from an observational cohort of patients with available partial pressure of oxygen (PaO2) was retrospectively assessed. Hyperoxia was defined as the highest quartile of PaO2 (≥173 mm Hg) and poor outcome as modified Rankin scale 4–6 three months after SAH. Of 252 included patients, there were no significant differences in baseline characteristics between patients with and without a history of hyperoxia. DCI occurred in 38.5% of patients and unfavourable …

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