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Response to a letter by Dr T Ramesh
  1. Andrew Eisen
  1. Correspondence to Dr Andrew Eisen, University of British Columbia, Neurology, 2862 Highbury Street Vancouver, British Columbia Canada V6R 3T6; eisen{at}

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We thank Dr Ramesh and colleagues in their letter1 for drawing our attention to their recent, important paper,2 showing very early, preclinical abnormalities in a Zebrafish model of amyotrophic lateral sclerosis (ALS), which we overlooked in our recent review, ‘Amyotrophic lateral sclerosis: a long preclinical period?’3 The Zebrafish findings are completely supportive of our contention …

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