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Noto and colleagues report on their use of nerve ultrasound to evaluate the peripheral nervous system (PNS) of patients with inherited neuropathies in the published study.1 They observed that nerves in patients with Charcot-Marie-Tooth neuropathy 1A (CMT1A), the most common form of CMT, had larger cross-sectional areas (CSA) than those from controls at all recording sites (median, sural, greater auricular nerves, C-6 root). Their observations are consistent with the known morphological2 and MRI3 findings in CMT1A of enlarged nerves. The greater auricular nerve in fact is often palpable because of its large size in CMT1A.4 The authors found that the median nerve was enlarged proximally and distally in patients with CMT1A by evaluating the wrist, mid-forearm and upper arm.1 Thus the ultrasound permitted analysis of the nerve along its length, a potential exciting advantage for its usage in the future. Mutations …
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