Article Text

other Versions

PDF
Research paper
Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation
  1. Takashi Tsuboi1,
  2. Hirohisa Watanabe1,
  3. Yasuhiro Tanaka1,
  4. Reiko Ohdake1,
  5. Noritaka Yoneyama1,
  6. Kazuhiro Hara1,
  7. Ryoichi Nakamura1,
  8. Hazuki Watanabe1,
  9. Jo Senda1,
  10. Naoki Atsuta1,
  11. Mizuki Ito1,
  12. Masaaki Hirayama1,
  13. Masahiko Yamamoto2,
  14. Yasushi Fujimoto3,
  15. Yasukazu Kajita4,
  16. Toshihiko Wakabayashi4,
  17. Gen Sobue1
  1. 1Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  2. 2Faculty of Psychological and Physical Science, Aichi-Gakuin University, Aichi, Japan
  3. 3Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  4. 4Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
  1. Correspondence to Gen Sobue, Department of Neurology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan; sobueg{at}med.nagoya-u.ac.jp

Abstract

Objectives To elucidate the phenotypes and pathophysiology of speech and voice disorders in Parkinson's disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS).

Methods We conducted a cross-sectional study on 76 PD patients treated with bilateral STN-DBS (PD-DBS) and 33 medically treated PD patients (PD-Med). Speech and voice functions, electrode positions, motor function and cognitive function were comprehensively assessed. Moreover, speech and voice functions were compared between the on-stimulation and off-stimulation conditions in 42 PD-DBS patients.

Results Speech and voice disorders in PD-DBS patients were significantly worse than those in PD-Med patients. Factor analysis and subsequent cluster analysis classified PD-DBS patients into five clusters: relatively good speech and voice function type, 25%; stuttering type, 24%; breathy voice type, 16%; strained voice type, 18%; and spastic dysarthria type, 17%. STN-DBS ameliorated voice tremor or low volume; however, it deteriorated the overall speech intelligibility in most patients. Breathy voice did not show significant changes and stuttering exhibited slight improvement after stopping stimulation. In contrast, patients with strained voice type or spastic dysarthria type showed a greater improvement after stopping stimulation. Spastic dysarthria type patients showed speech disorders similar to spastic dysarthria, which is associated with bilateral upper motor neuron involvement. Strained voice type and spastic dysarthria type appeared to be related to current diffusion to the corticobulbar fibres.

Conclusions Stuttering and breathy voice can be aggravated by STN-DBS, but are mainly due to aging or PD itself. Strained voice and spastic dysarthria are considered corticobulbar side effects.

  • PARKINSON'S DISEASE
  • MOVEMENT DISORDERS
  • STEREOTAXIC SURGERY
  • SPEECH

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.