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In their JNNP paper Tsujikawa et al characterise Parkinson disease (PD) at the early stages in 70 patients, according to 123I-meta-iodobenzylguanidine (mIBG) myocardial scintigraphic, and report its chronological changes (mean follow-up 3 years) with its symptoms relationship.1
123I-mIBG is a Norepinefrine (NE) analogue that competes with NE for the same transporter mechanism of postganglionar adrenergic neurons. The uptake of mIBG into neurons is achieved mainly through the uptake-1 mechanism, a high affinity homeostatic system responsible for the reuptake of NE. Receptors for NE or mIBG are located on the synapse in sympathetic terminal nerve axons; once in the axon, the tracer is transported in the axoplasm to …
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