Article Text

other Versions

PDF
Are neurofilaments heading for the ALS clinic?
  1. Martin R Turner,
  2. Elizabeth Gray
  1. Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK
  1. Correspondence to Professor Martin Turner, Clinical Neurosciences, West Wing Level 3, John Radcliffe Hospital, Oxford OX3 9DU, UK; martin.turner{at}ndcn.ox.ac.uk

Statistics from Altmetric.com

The neurodegenerative disorder amyotrophic lateral sclerosis (ALS, the commonest phenotype within the broad term motor neuron disease) is not one disease aetiologically. There is also a wide range of disease progression rate around a median survival of 3 years from symptom onset, and it has remained a quintessentially clinical diagnosis.1 Diagnostic delay, phenotype heterogeneity and a reliance on survival as the main outcome measure, all conspire to necessitate large and lengthy therapeutic trial designs and have brought the development of biomarkers to the forefront of research efforts. In their JNNP paper, Steinacker et al2 further strengthen the emerging diagnostic and prognostic value of cerebrospinal fluid (CSF) neurofilaments across an unprecedentedly large number of patients with ALS compared to those with a range of other neurological conditions.

Neurofilaments are the scaffolding of the nervous system, and classified according to the molecular mass …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Neuromuscular
    Petra Steinacker Emily Feneberg Jochen Weishaupt Johannes Brettschneider Hayrettin Tumani Peter M Andersen Christine A F von Arnim Sarah Böhm Jan Kassubek Christian Kubisch Dorothée Lulé Hans-Peter Müller Rainer Muche Elmar Pinkhardt Patrick Oeckl Angela Rosenbohm Sarah Anderl-Straub Alexander E Volk Patrick Weydt Albert C Ludolph Markus Otto