Article Text

other Versions

PDF
Research paper
Defining and validating a short form Montreal Cognitive Assessment (s-MoCA) for use in neurodegenerative disease
  1. David R Roalf*1,
  2. Tyler M Moore1,
  3. David A Wolk2,3,
  4. Steven E Arnold2,3,
  5. Dawn Mechanic-Hamilton1,3,
  6. Jacqueline Rick4,
  7. Sushila Kabadi1,
  8. Kosha Ruparel1,
  9. Alice S Chen-Plotkin2,
  10. Lama M Chahine2,
  11. Nabila A Dahodwala2,
  12. John E Duda2,5,
  13. Daniel A Weintraub1,2,4,5,
  14. Paul J Moberg1,2,3
  1. 1Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  2. 2Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  3. 3Alzheimer's Disease Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  4. 4Udall Center for Parkinson's Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  5. 5Parkinson's Disease Research, Education and Clinical Center (PADRECC) at the Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA
  1. Correspondence to Dr David R Roalf, Department of Psychiatry, Neuropsychiatry Section, Brain Behavior Laboratory, Hospital of the University of Pennsylvania, 10th Floor, Gates Building, Philadelphia, PA 19104, USA; roalf{at}upenn.edu

Abstract

Introduction Screening for cognitive deficits is essential in neurodegenerative disease. Screening tests, such as the Montreal Cognitive Assessment (MoCA), are easily administered, correlate with neuropsychological performance and demonstrate diagnostic utility. Yet, administration time is too long for many clinical settings.

Methods Item response theory and computerised adaptive testing simulation were employed to establish an abbreviated MoCA in 1850 well-characterised community-dwelling individuals with and without neurodegenerative disease.

Results 8 MoCA items with high item discrimination and appropriate difficulty were identified for use in a short form (s-MoCA). The s-MoCA was highly correlated with the original MoCA, showed robust diagnostic classification and cross-validation procedures substantiated these items.

Discussion Early detection of cognitive impairment is an important clinical and public health concern, but administration of screening measures is limited by time constraints in demanding clinical settings. Here, we provide as-MoCA that is valid across neurological disorders and can be administered in approximately 5 min.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.