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Review
Amyotrophic lateral sclerosis and motor neuron syndromes in Asia
  1. N Shahrizaila1,2,
  2. G Sobue3,
  3. S Kuwabara4,
  4. S H Kim5,
  5. Carol Birks6,
  6. D S Fan7,
  7. J S Bae8,
  8. C J Hu9,
  9. M Gourie-Devi10,
  10. Y Noto2,11,
  11. K Shibuya2,4,
  12. K J Goh1,
  13. R Kaji12,
  14. CP Tsai13,
  15. L Cui14,
  16. P Talman15,
  17. R D Henderson16,
  18. S Vucic17,
  19. M C Kiernan2
  1. 1Faculty of Medicine, Neurology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  2. 2Brain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia
  3. 3Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  4. 4Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
  5. 5Department of Neurology, Hanyang University Medical Center, Seoul, South Korea
  6. 6International Alliance of ALS/MND Associations, Sydney, New South Wales, Australia
  7. 7Department of Neurology, Peking University Third Hospital, Beijing, China
  8. 8Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea
  9. 9Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
  10. 10Department of Neurology, Institute of Human Behaviour and Allied Sciences (IHBAS), New Delhi, Delhi, India
  11. 11Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
  12. 12Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
  13. 13Department of Neurology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
  14. 14Department of Neurology, Peking Union Medical College Hospital, Beijing, China
  15. 15Neurology Unit, Calvary Health Care, Bethlehem Hospital, Caulfield, Victoria, Australia
  16. 16Department of Neurology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
  17. 17The Brain Dynamics Centre, Westmead Millennium Institute, Westmead, NSW and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
  1. Correspondence to Dr N Shahrizaila, Neurology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, Malaysia; nortina{at}um.edu.my

Abstract

While the past 2 decades have witnessed an increasing understanding of amyotrophic lateral sclerosis (ALS) arising from East Asia, particularly Japan, South Korea, Taiwan and China, knowledge of ALS throughout the whole of Asia remains limited. Asia represents >50% of the world population, making it host to the largest patient cohort of ALS. Furthermore, Asia represents a diverse population in terms of ethnic, social and cultural backgrounds. In this review, an overview is presented that covers what is currently known of ALS in Asia from basic epidemiology and genetic influences, through to disease characteristics including atypical phenotypes which manifest a predilection for Asians. With the recent establishment of the Pan-Asian Consortium for Treatment and Research in ALS to facilitate collaborations between clinicians and researchers across the region, it is anticipated that Asia and the Pacific will contribute to unravelling the uncertainties in ALS.

  • ALS
  • MOTOR NEURON DISEASE
  • EPIDEMIOLOGY

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