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Research paper
Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis
  1. Zhang-Yu Zou1,
  2. Zhi-Rui Zhou2,3,
  3. Chun-Hui Che1,
  4. Chang-Yun Liu1,
  5. Rao-Li He1,
  6. Hua-Pin Huang1
  1. 1Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China
  2. 2Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
  3. 3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
  1. Correspondence to Dr Zhang-Yu Zou, Department of Neurology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China; pumczzy{at}gmail.com or Hua-Pin Huang, Department of Neurology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Gulou District, Fuzhou, 350001, Fujian, China hh_p{at}163.com

Abstract

Background Genetic studies have shown that C9orf72, SOD1, TARDBP and FUS are the most common mutated genes in amyotrophic lateral sclerosis (ALS). Here, we performed a meta-analysis to determine the mutation frequencies of these major ALS-related genes in patients with ALS.

Methods We performed an extensive literature research to identify all original articles reporting frequencies of C9orf72, SOD1, TARDBP and FUS mutations in ALS. The mutation frequency and effect size of each study were combined. Possible sources of heterogeneity across studies were determined by meta-regression, sensitivity analysis and subgroup analysis.

Results 111 studies were included in the meta-analysis. The overall pooled mutation frequencies of these major ALS-related genes were 47.7% in familial amyotrophic lateral sclerosis (FALS) and 5.2% in sporadic ALS (SALS). A significant difference was identified regarding the frequencies of mutations in major ALS genes between European and Asian patients. In European populations, the most common mutations were the C9orf72 repeat expansions (FALS 33.7%, SALS 5.1%), followed by SOD1 (FALS 14.8%, SALS 1.2%), TARDBP (FALS 4.2%, SALS 0.8%) and FUS mutations (FALS 2.8%, SALS 0.3%), while in Asian populations the most common mutations were SOD1 mutations (FALS 30.0%, SALS 1.5%), followed by FUS (FALS 6.4%, SALS 0.9%), C9orf72 (FALS 2.3%, SALS 0.3%) and TARDBP (FALS 1.5%, SALS 0.2%) mutations.

Conclusions These findings demonstrated that the genetic architecture of ALS in Asian populations is distinct from that in European populations, which need to be given appropriate consideration when performing genetic testing of patients with ALS.

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Footnotes

  • Contributors Z-YZ was involved in the study concept, literature search, data extraction, analysis and interpretation of the data, statistical analysis, and drafting/revising the manuscript. Z-RZ and C-HC were involved in the literature search, data extraction, analysis and interpretation of the data and revising the manuscript. C-YL, R-LH were involved in the analysis and interpretation of the data and revising the manuscript. H-PH was involved in the analysis and interpretation of the data, as well as in revising the manuscript and study coordination.

  • Funding This study was supported by the National Science Foundation of Fujian (2015J01395) and National Natural Science Foundation of China (grant number 81671271).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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