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Observing conversational laughter in frontotemporal dementia
  1. Peter S Pressman1,2,3,
  2. Michaela Simpson3,
  3. Kelly Gola2,
  4. Suzanne M Shdo2,
  5. Edoardo G Spinelli2,
  6. Bruce L Miller2,
  7. Maria Luisa Gorno-Tempini2,
  8. Katherine Rankin2,
  9. Robert W Levenson3
  1. 1 Rocky Mountain Alzheimer’s Disease Center, Department of Neurology, University of Colorado, Denver, Colorado, USA
  2. 2 Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA
  3. 3 Berkeley Psychophysiology Laboratory, University of California, Berkeley, California, USA
  1. Correspondence to Dr Peter S Pressman, Memory and Aging Center, Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, California 94158, USA; ppressman{at}memory.ucsf.edu, peter.pressman{at}ucdenver.edu

Abstract

Background We performed an observational study of laughter during seminaturalistic conversations between patients with dementia and familial caregivers. Patients were diagnosed with (1) behavioural variant frontotemporal dementia (bvFTD), (2) right temporal variant frontotemporal dementia (rtFTD), (3) semantic variant of primary progressive aphasia (svPPA), (4) non-fluent variant primary progressive aphasia (nfvPPA) or (5) early onset Alzheimer’s disease (eoAD). We hypothesised that those with bvFTD would laugh less in response to their own speech than other dementia groups or controls, while those with rtFTD would laugh less regardless of who was speaking.

Methods Patients with bvFTD (n=39), svPPA (n=19), rtFTD (n=14), nfvPPA (n=16), eoAD (n=17) and healthy controls (n=156) were recorded (video and audio) while discussing a problem in their relationship with a healthy control companion. Using the audio track only, laughs were identified by trained coders and then further classed by an automated algorithm as occurring during or shortly after the participant’s own vocalisation ('self' context) or during or shortly after the partner’s vocalisation ('partner' context).

Results Individuals with bvFTD, eoAD or rtFTD laughed less across both contexts of self and partner than the other groups. Those with bvFTD laughed less relative to their own speech comparedwith healthy controls. Those with nfvPPA laughed more in the partner context compared with healthy controls.

Conclusions Laughter in response to one’s own vocalisations or those of a conversational partner may be a clinically useful measure in dementia diagnosis.

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