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Review
7T MRI for neurodegenerative dementias in vivo: a systematic review of the literature
  1. Elizabeth Frances McKiernan,
  2. John Tiernan O'Brien
  1. Department of Psychiatry, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK
  1. Correspondence to Dr Elizabeth Frances McKiernan, Department of Psychiatry, School of Clinical Medicine, Cambridge Biomedical Campus, University of Cambridge, Box 189, Level E4, Cambridge CB2 0SP, UK; em654{at}medschl.cam.ac.uk

Abstract

The spatial resolution of 7T MRI approaches the scale of pathologies of interest in degenerative brain diseases, such as amyloid plaques and changes in cortical layers and subcortical nuclei. It may reveal new information about neurodegenerative dementias, although challenges may include increased artefact production and more adverse effects. We performed a systematic review of papers investigating Alzheimer’s disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD) and Huntington’s disease (HD) in vivo using 7T MRI. Of 19 studies identified, 15 investigated AD (the majority of which examined hippocampal subfield changes), and 4 investigated HD. Ultrahigh resolution revealed changes not visible using lower field strengths, such as hippocampal subfield atrophy in mild cognitive impairment. Increased sensitivity to susceptibility-enhanced iron imaging, facilitating amyloid and microbleed examination; for example, higher microbleed prevalence was found in AD than previously recognised. Theoretical difficulties regarding image acquisition and scan tolerance were not reported as problematic. Study limitations included small subject groups, a lack of studies investigating LBD and FTD and an absence of longitudinal data. In vivo 7T MRI may illuminate disease processes and reveal new biomarkers and therapeutic targets. Evidence from AD and HD studies suggest that other neurodegenerative dementias would also benefit from imaging at ultrahigh resolution.

  • 7T MRI
  • neurodegenerative dementia, Alzheimer’s disease
  • Lewy body dementia
  • frontotemporal dementia
  • Huntington’s disease

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Footnotes

  • Contributors EFM and JTO conceptualised this systematic review. EFM performed the literature search and reviewed the papers with supervision from JTO. EFM drafted the written paper which was revised by JTO. The authors take joint responsibility for the accuracy and integrity of this work.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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