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Neuropsychiatric syndromes of multiple sclerosis
  1. Ruth Murphy1,
  2. Stefani O’Donoghue2,
  3. Timothy Counihan3,
  4. Colm McDonald2,
  5. Peter A Calabresi4,
  6. Mohammed AS Ahmed5,
  7. Adam Kaplin4,
  8. Brian Hallahan2
  1. 1Department of Psychiatry, University College Hospital Galway, Galway, Ireland
  2. 2Department of Psychiatry, National University of Ireland, Galway, Ireland
  3. 3Department of Neurology, National University of Ireland, Galway, Ireland
  4. 4Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
  5. 5Departments of Medical Education and Psychiatry, Hamad Medical Corporation, Doha, Qatar
  1. Correspondence to Brian Hallahan, Department of Psychiatry, National University of Ireland, NUI Galway, Galway, Ireland; brian.hallahan{at}


Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis (MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or more commonly with disease progression. However, the pathogenesis of these comorbid conditions remains unclear and it remains difficult to accurately elucidate if neuropsychiatric symptoms or conditions are indicators of MS illness severity. Furthermore, both the disease process and the treatments of MS can adversely impact an individual's mental health. In this review, we discuss the common neuropsychiatric syndromes that occur in MS and describe the clinical symptoms, aetiology, neuroimaging findings and management strategies for these conditions.

  • Multiple Sclerosis
  • Depression
  • Bipolar Disorder
  • Psychosis
  • Magnetic Resonance Imaging

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  • Contributors RM: study design, methodology, write-up; SO’D: study design, write-up; TC: study design, review of article; CMcD: study design, review of article; BH: study design, write-up, review of article.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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