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Research paper
An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event
  1. Prudence Tettey1,
  2. Steve Simpson1,2,
  3. Bruce Taylor1,
  4. Anne-Louise Ponsonby3,
  5. Robyn M Lucas4,
  6. Terence Dwyer3,
  7. Karam Kostner5,
  8. AUSLONG investigators group,
  9. Ingrid AF van der Mei1
  1. 1 Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
  2. 2 Turning Point, Monash University, Fitzroy, Australia
  3. 3 Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia
  4. 4 National Centre for Epidemiology and Population Health, Research School of Population Health, College of Medicine, Biology and Environment, Australian National University, Canberra, Australia
  5. 5 Mater Hospital, University of Queensland, Queensland, Australia
  1. Correspondence to Mr Prudence Tettey, Menzies Institute for Medical ResearchUniversity of Tasmania, Hobart, Tasmania 7000, Australia; prudence.tettey{at}utas.edu.au

Abstract

Objective To investigate the prospective associations between adiposity and lipid-related variables and conversion to multiple sclerosis (MS), time to subsequent relapse and progression in disability.

Methods A cohort of 279 participants with a first clinical diagnosis of central nervous system demyelination was prospectively followed to 5-year review. Height, weight, waist and hip circumference were measured, and serum samples taken for measurement of lipids and apolipoproteins. Survival analysis was used for conversion to MS and time to relapse, and linear regression for annualised change in disability (Expanded Disability Status Scale).

Results Higher body mass index (BMI; adjusted HR (aHR): 1.22 (1.04 to 1.44) per 5 kg/m2 increase), hip circumference (aHR: 1.32 (1.12 to 1.56) per 10 cm increase) and triglyceride levels (aHR: 1.20 (1.03 to 1.40) per unit increase) were associated with increased risk of subsequent relapse, while adiposity and lipid-related measures were not associated with conversion to MS. In addition, higher BMI (β: 0.04 (0.01 to 0.07) per 5 kg/m2 increase), hip circumference (β: 0.04 (0.02 to 0.08) per 10 cm increase), waist circumference (β: 0.04 (0.02 to 0.07) per 10 cm increase), total cholesterol to high-density lipoprotein ratio (TC/HDL ratio; β: 0.05 (0.001 to 0.10) and non-HDL; β: 0.04 (0.001 to 0.08) at study entry) were associated with a higher subsequent annual change in disability.

Conclusions Higher levels of adiposity, non-HDL and TC/HDL ratio were prospectively associated with a higher rate of disability progression, and higher adiposity and triglycerides were associated with relapse but not with conversion to MS. Improving the lipid profile and losing weight into the healthy range could reduce the accumulation of disability.

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Footnotes

  • Contributors The AusLong Study was designed and implemented by BT, IvM, SSJ, RML, A-LP and TD. Lipid measurements were performed by KK. Analyses were performed by PT. Initial drafting of the manuscript was by PT, SSJ, BT and IvM. All authors participated in critical revision of the manuscript.

  • Funding The AusLong Study was funded by a grant from the Australian National Health and Medical Research Council (NHMRC APP544922) .

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Presentation statement A full list of the members of the AUSLONG investigators group is provided in the Acknowledgements.

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