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Cerebellar atrophy in neurodegeneration—a meta-analysis
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  • Published on:
    Does Cerebellar Atrophy in Neurodegeneration?
    • Li-Qin Sheng, Neurologist Department of Neurology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, PR China
    • Other Contributors:
      • Ping-Lei Pan, Neurologist

    Does Cerebellar Atrophy in Neurodegeneration?

    Li-Qin Sheng1, Ping-Lei Pan2
    1 Department of Neurology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, PR China
    2 Department of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China

    Correspondence:
    PingLei Pan, Department of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, West Xindu Road 2#, Yancheng, Jiangsu Province, 224001, PR China. E-mail: panpinglei@163.com, Telephone: +8618361146977

    Coordinate-based meta-analysis is a powerful way for neuroimaging studies to identify the most consistent and replicable differences in brain activity or structure in neurodegenerative disorders. In their JNNP publication, Gellersen et al 1 conducted coordinate-based meta-analyses of 54 voxel-based morphometry (VBM) studies in Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), behavioral variant frontotemporal dementia (bvFTD), amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). In this study, they solely focused on cerebellar grey matter (GM) atrophy.1 Marked cerebellar atrophy in AD, ALS, bvFTD, PSP and MSA, but not in PD or HD, was identified in the meta-analyses.1
    These findings are of interest.1 However, the procedure of the meta-analyses had a major limitation. Coordin...

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    Conflict of Interest:
    None declared.