Article Text

PDF
Pseudobulbar affective disorder, emotion and the brain
  1. Michael Swash1,
  2. Michael R Trimble2
  1. 1Department of Neurology, Royal London Hospital, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  2. 2Department of Behavioural Neurology, Institute of Neurology, University College London, London, UK
  1. Correspondence to Professor Michael Swash, Department of Neurology, The Royal London Hospital, London, UK EC2Y 8BL; mswash{at}btinternet.com

Statistics from Altmetric.com

Emotional expression and cognition are unlinked in pseudobulbar affective disorder

In the past half-century, the neuroanatomical regulators of emotion have become better understood. The rediscovery of the limbic areas and their intimate links with the basal ganglia, especially the ventral striatum and associated orbitofrontal cortex, and the special role of the right hemisphere in emotional experience has been central to this understanding.1 However, the complexity of the relationship between these circuits and areas of isocortex and the descending pathways to midbrain and brainstem nuclei in volitional and emotional faciobulbar expression remain less well understood. Emotional disorder is a major feature of frontal brain disease, and complex emotional states and gelastic seizures are well-recognised features of some forms of epilepsy. Uncontrolled, disabling and unstable mood change characteristics of pseudobulbar affective disorder may develop after diffuse traumatic brain injury, in frontal or multi-infarct cerebrovascular disease, multiple sclerosis and degenerative brain diseases, which can lead to depressive illness, bipolar disorder and emotional lability.

The relationship between the experience of emotion and its motor expression was first clearly formulated in 1884–1885 in the James-Lange theory of the emotions. …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Neurodegeneration
    Nimish J Thakore Erik P Pioro