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Marriage and risk of dementia: systematic review and meta-analysis of observational studies
  1. Christopher P L H Chen1,
  2. Vincent C T Mok2
  1. 1Departments of Pharmacology and Psychological Medicine, Memory Aging & Cognition Centre, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore
  2. 2Department of Medicine & Therapeutics, Faculty of Medicine, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Gerald Choa Neuroscience Research Centre, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
  1. Correspondence to Dr Christopher P L H Chen, Departments of Pharmacology and Psychological Medicine, Memory Aging & Cognition Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; phccclh{at}nus.edu.sg

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You don’t have to be demented to be married, but it sure helps

This JNNP meta-analysis, which included 15 studies with 812 047 participants, showed an elevated dementia risk in lifelong single (42%) and widowed (20%) but not divorced persons compared with those who were married1. Although one study from Sweden contributed the vast majority (92%) of participants, the other studies were also broadly in agreement and, importantly, came from a wide range of countries across the world: Europe (France, Germany, Italy, Sweden), North and South America (Brazil, USA) and Asia (China, Japan, South Korea, Taiwan). Furthermore, the robustness of the association was shown by sensitivity analyses for demographic factors (sex, whether study subjects were born before or after 1927) and study methodology (type, quality). However, the association with dementia subtypes …

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