eLetters

190 e-Letters

published between 2006 and 2009

  • Diffusion restriction in an early phase of Wallerian degeneration along the corticospinal tract.
    Toshio Moritani

    This is a typical case of diffusion restriction in an early phase of Wallerian degeneration along the left corticospinal tract secondary to a large left putaminal hemorrhage. Diffusion weighted (DW) imaging shows the early phase of wallerian degeneration as hyperintense associated with decreased ADC, presumably representing axonal and reactive astrocytic swelling [1, 2]. DW high signals can be observed after more than 24...

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  • Predicting the risk of aneurysm rupture is something different than identifying risk factors.
    Jacoba P. Greving

    Dear Editor,

    With interest we read the article by You et al. describing the identification of risk factors for aneurysm rupture and providing estimations for the likelihood of rupture in unruptured intracranial aneurysms [1]. However, we have concerns about the study design, the presented analysis and the conclusions regarding the predictors for aneurysm rupture.

    First, the authors used a study popul...

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  • Weight gain following subthalamic deep brain stimulation in Parkinson's disease
    Harrison C. Walker

    Dear Editor,

    We read with interest the manuscript by Bannier et al[1] describing weight gain at 16 months following bilateral subthalamic nucleus deep brain stimulation (STN DBS) placement in patients with Parkinson's disease (PD). The authors concluded that weight gain following DBS is “life- threatening,” increases cardiovascular risk, and is more than a mere normalization towards a baseline weight in the absenc...

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  • Brainstem involvement in neuromyelitis optica
    Kai Chen Wang

    Dear Editor,

    I read with interest the article by Viegas et al. 1 about the symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica (NMO). Their case review of a young lady presented with spontaneous vomiting and behavioral change, confirmed the diagnosis of NMO after the identification of aquaporin 4 antibody(AQP4 Ab).

    We also have many patients presented with...

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  • The role of cerebrospinal fluid glial fibrillar acidic protein levels in neuromyelitis optica
    Roberta M S Costa

    Dear Editor,

    In the article “Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker” J. Neurol. Neurosurg. Psychiatry 2009;80;575-577, the authors found a significant increase in the CSF-GFAP levels during relapse in NMO patients which were several thousand times higher than those found in other neurological diseases (MS, OND, spinal infarct...

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  • Status epilepticus: is it time to change the protocol?
    Nitin K Sethi

    Dear Editor,

    I read with interest the case report by Schulze-Bonhage et al. documenting the termination of complex partial status epilepticus in a patient following the intravenous administration of levetiracetam 1. Schulze-Bonhage’s patient had seizures refractory to multiple frontline anti-epileptic medications and lapsed into complex partial status epilepticus when her pre-admission seizure medications were...

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  • Demyelinating peripheral neuropathy and relapsing central demyelination:do we need more splitting ?
    Giuliana Galassi

    Autoimmune diseases are caused by aberrant response of immune system directed against triggering epitopes.(1)Coincidental occurrence of multiple autoimmune disorders in given patient suggests either common or similar pathogenetic mechanisms.(1)The concept of molecular mimicry hold that an agent may share epitopic determinants with nervous system tissues and incites immune responses. Chronic inflammatory demyelinating po...

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  • Pierre Mollaret (1898-1987) and his legacy to science. An addendum
    Juan J Zarranz

    Dear Editor,

    I came across the article of Dr. Sarikcioglu and Dr. Sindel (1) and I would like to add a few additional items on the contributions of Professor Pierre Mollaret to science and in particular to Neurology. Dr. Mollaret was a Professor of General Pathology who dedicated most of his time to the study of both the treatment and the epidemiology of infectious diseases. Nevertheless he had a real interest in...

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  • Re: Are intravenous immunoglobulines truly beneficial in diabetic patients with CIDP?
    Stefano Jann

    Dear Editor,

    we are indebted with Dr. Josef Finsterer and Dr. Marlies Frank because they give us the chance to explain some points of our paper. We will reply to their concerns as requested.

    We followed the most restrictive diagnostic criteria of the AAN because we needed to extremely select our patients. Our neurophysiological criteria are slightly more restrictive than the AAN criteria and we have r...

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  • Memory performance is related to amyloid and tau pathology in the hippocampus: a Response
    Dr. Bhavani Shankara Bagepally

    Dear editor

    It is interesting to note that, Figure 3 Shows that Mean Memory factor score for Neurofibrillary tangles(NFT) score-5 is 40.1,30.3 and 13.0 for plaques in CA1, plaques in subiculum and plaques in entorhinal cortex respectively which is less compared to the memory scores of higher NFT scores like 5 to 15 and >15. But this can be cautiously interpreted as memory scoring is not directly related t...

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