550 e-Letters

  • Also patients with dementia need motor examination, but do we need more examination tools?
    Liuba Papeo

    In an editorial commentary accompanying a recent study on the prevalence of apraxia in dementia patients [1], Bak emphasizes two facts: 1) research in cognitive neuroscience is contributing to increase the awareness of a close relationship between cognitive and motor functions and, by extension, cognitive and motor disorders in clinical populations; 2) despite so, the examination of motor functions in patients with cogn...

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    Simona Balestrini

    Sir, We thank Kumar et al. for their interest in our recent article on retinal nerve fibre layer thickness (RNFL) in people with epilepsy. In their letter they raise a few points that we would like to address.

    1. Comparison between people with epilepsy and healthy controls. They suggest that a comparison between people with drug-resistant versus non- resistant epilepsy might have been more appropriate. However, a...

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    Amith Kumar

    Sir, The recently published article titled "Retinal nerve fibre layer thinning is associated with drug resistance in epilepsy" by Balestrini S et al has been a refreshing approach into a common menace - refractory epilepsy. 30 to 40% of patients with seizure are classified as persistent seizures under AEDs among which refractory epilepsy is included. (1) Retinal nerve fibre layer (RNFL) thinning is an easy and non invas...

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  • Short Montreal Cognitive Assessment (s-MOCA): validation study
    Andrew J. Larner

    Roalf et al. describe a short form of the Montreal Cognitive Assessment (s-MOCA) comprising 8 items (score range 0-16) from the original MoCA.

    Data from a historical cohort administered the MoCA (n = 150)1 were examined to extract s-MoCA scores. There was high correlation between s- MoCA scores and MoCA and MMSE scores (0.94, 0.80 respectively).

    s-MoCA scores differed significantly (null hypothesis r...

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  • Response to 'The prognosis of acute symptomatic seizures after ischaemic stroke'.
    Elizabeth C. Galizia

    We read with interest the findings and recommendations by the authors. (1)

    Cerebrovascular disease accounts for the increasing burden of seizures and epilepsy in people over the age of 65 years. The distinction between acute and remote symptomatic seizures is highly relevant with implications both for prognosis and clinical management. Acute symptomatic seizures (ASS) following a cerebrovascular event are def...

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  • Leg stereotypy disorder: Not true stereotypy
    Sanjay Pandey
    We read the viewpoint on leg stereotypy1 by Joseph Jankovic with great interest. He has described leg stereotypy as repetitive, 1-4 Hz flexion extension, abduction-adduction movement at hips when the patient is seated and the feet rest on the floor.1 This movement has also been described to manifest as flexion extension at the knee joint or as tapping movement of foot.1 Patients as per this description have also been found to have...
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  • Meta-analysis by Xu et al. suffers from critical errors
    Evangelos Evangelou

    The meta-analysis by Xu et al is a valiant effort to map the evidence for modifiable risk factors of Alzheimer's disease (AD) (1). We acknowledge this huge effort, however, we have serious concerns regarding the systematic appraisal and the synthesis of the available data.

    On top of the critique by Drs. Wu and Brayne (e-letter), a comprehensive assessment of the article and its results can reveal critical error...

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  • Re:"Correction to odds ratio"
    Sascha K?pke

    Dear Editor,

    We thank Dr. Solari for pointing out an aspect of possible misunderstanding, but surely not incorrectness. We agree that the reverse odds ratio of 5.63 (95% CI 2.87 to 11.05, p<0.001) would more clearly refer to the odds of achieving informed choice. Still the reported odds ratio of 0.18 (95% CI 0.09 to 0.35, p<0.001) gives exactly the same information and is probably more intuitively underst...

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  • "Correction to odds ratio"
    Alessandra Solari

    I enjoyed reading the paper of Sascha Kopke et al. [1] on the efficacy of an evidence-based information program for people with recently diagnosed multiple sclerosis. I noticed, however that the odds ratio (OR) for the primary endpoint (achieving 'informed choice') is incorrect, both in the Abstract and in the Results.

    Abstract: 'For the primary endpoint, a significant difference was shown with 50 of 85 (59%) pa...

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  • Thiamine compounds in humans
    Marco Poloni

    I have some comments concerning the report by S. Jesse, D.R. Thal and A.C. Ludolph, recently published in JNNP September 15 2015, pag. 1166-1168 "Thiamine deficiency in Amyotrophic Lateral Sclerosis". In a research dated 1981 Rindi et al. showed that in 12 CSF samples obtained from different healthy subjects, without any clinical disorder involving thiamin status, the only thiamin compounds detected after electrophoretic...

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