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Constipation in Parkinson's disease

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Summary

Constipation is a frequent symptom in Parkinson's disease. In this study colonic transit time was measured in 20 patients and 20 sex- and age-matched controls. Colonic transit was normal in all but two of the controls. In 16 patients with Parkinson's disease the average colonic passage was 5 to 7 days. For four patients transit-time was within normal limits. The delayed transport affected all sections of the colon. There was no obvious dependence on age, sex, presentation of the disease, physical activity, or medication. In our opinion, lesions of the autonomic nervous system are responsible.

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References

  1. Aminoff MJ, Wilcox CS (1971) Assessment of autonomic function in patients with a Parkinsonian syndrome. Br Med J 4:80–84

    Google Scholar 

  2. Arhan P, Devroede G, Jehannin B, Lanza M, Faverdin C, Dornic C, Persoz B, Tétreault L, Perey B, Pellerin D (1981) Segmental colonic transit time. Dis Colon Rectum 24:625–629

    Google Scholar 

  3. Beuret-Blanquart F, Weber J, Gouverneur JP, Demangeon S, Denis P (1990) Colonic transit time and anorectal manometric anomalies in 19 patients with complete transection of the spinal cord. J Auton Nerv Syst 30:199–208

    Google Scholar 

  4. Den Hartog, Jager WA, Bethlem J (1960) The distribution of Lewy bodies in the central and autonomic nervous system in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatry 23:283–290

    Google Scholar 

  5. Eadie MJ (1963) The pathology of certain medullary nuclei in parkinsonism. Brain 86:781–792

    Google Scholar 

  6. Eadie MJ, Tyrer JH (1965) Alimentary disorders in parkinsonism. Aust Ann Med 14:13–22

    Google Scholar 

  7. Eastwood HDH (1972) Bowel transit studies in the elderly-radio-opaque markers in the investigation of constipation. Geront Clin 14:154–159

    Google Scholar 

  8. Gibberd FB, Gleeson JA, Gossage AAR, Wilson RSE (1974) Oesophageal dilatation in Parkinson's disease. J Neurol Neurosurg Psychiatry 37:938–940

    Google Scholar 

  9. Hinton JM, Lennard-Jones JE, Young AC (1969) A new method for studying gut transit times using radioopaque markers. Gut 10:842–847

    Google Scholar 

  10. Kempster PA, Lees AJ, Frankel JP, Shorvon P (1989) Offperiod belching due to a reversible disturbance of oesophageal motility in Parkinson's disease and its treatment with apomorphine. Mov Disord 4:47–52

    Google Scholar 

  11. Korczyn AD (1989) Autonomic nervous system screening in patients with early Parkinson's disease. In: Przuntek H, Riederer P (eds) Early diagnosis and preventive therapy in Parkinson's disease. Springer, Wien, pp 41–48

    Google Scholar 

  12. Kupsky WJ, Grimes MM, Sweeting J, Bertsch R, Cote LJ (1987) Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells. Neurology 37:1253–1255

    Google Scholar 

  13. Lewy FH (1912) Paralysis agitans. I. Pathologische Anatomie. In: M. Lewandowsky (ed) Handbuch der Neurologie, III. Bd., Springer, Berlin Heidelberg New York, pp 920–933

    Google Scholar 

  14. Martelli H, Devroede G, Arhan P, Duguay C, Dornic C, Faverdin C (1978) Some parameters of large bowel motility in normal man. Gastroenterology 75:612–618

    Google Scholar 

  15. Mathers SE, Kempster PA, Swash M, Lees AJ (1988) Constipation and paradoxical puborectalis contraction in anismus and Parkinson's disease: a dystonic phenomenon? J Neurol Neurosurg Psychiatry 51:1503–1507

    Google Scholar 

  16. Mathers SE, Kempster PA, Law PJ, Frankel JP, Bartram CI, Lees AJ, Stern GM, Swash M (1989) Anal sphincter dysfunction in Parkinson's disease. Arch Neurol 46:1061–1064

    Google Scholar 

  17. Ohama E, Ikuta F (1976) Parkinson's disease: distribution of Lewy bodies and monoamine neuron system. Acta Neuropathol 34:311–319

    Google Scholar 

  18. Parkinson J (1817) An essay on the shaking palsy. Sherwood, Neely and Jones, London

    Google Scholar 

  19. Qualman SJ, Haupt HM, Yang P, Hamilton SR (1984) Esophageal Lewy bodies associated with ganglion loss in achalasia. Gastroenterology 87:848–856

    Google Scholar 

  20. Webster DD (1968) Modern treatment: critical analysis of the disability in Parkinson's disease. Harper and Row, New York, pp 257–282

    Google Scholar 

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Jost, W.H., Schimrigk, K. Constipation in Parkinson's disease. Klin Wochenschr 69, 906–909 (1991). https://doi.org/10.1007/BF01798536

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  • DOI: https://doi.org/10.1007/BF01798536

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