Abstract
Although substantial research has been conducted on chronic fatigue syndrome (CFS) over the past decade, the syndrome remains poorly understood. The most recent case definition describes CFS as being characterized both by disabling fatigue and by subjective reports of difficulty with concentration and “short-term” memory. However, research into the neurocognitive and psychological functioning of individuals with CFS has provided mixed objective results. The current paper reviews studies that have examined the neurocognitive and/or psychological functioning of individuals with CFS. Changes in research design and instruments employed to study individuals with CFS are suggested.
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Abbey, S., and Garfinkle, P. (1991). Chronic fatigue syndrome and depression: Cause, effect, or covariate.Reviews of Infectious Diseases 13(Suppl 1): S73–83.
Altay, H. T., Abbey, S. E., Toner, B. B., Salit, I. E., Brooker, H., and Garfinkel, P. E. (1990). The neuropsychological dimensions of postinfectious neuromyasthenia (Chronic Fatigue Syndrome): A preliminary report.International Journal of Psychiatry in Medicine 20: 141–149.
Bearn, W., and Wessely, S. (1994). Neurobiological aspects of the chronic fatigue syndrome.European Journal of Clinical Investigation 24: 79–90.
Cadet, J., and Lohr, J. (1987). Neuropsychiatric aspects of infectious and inflammatory diseases of the central nervous system. In Hales, R., and Yudofsky, S. (eds.),The American Psychiatric Press Textbook of Neuropsychiatry, American Psychiatric Press, Washington, DC, 339–350.
Costa, D., Brostoff, J., Douli, V., and Ell, P. (1992). Postviral fatigue syndrome.British Medical Journal 304: 1567.
DaCosta, J. (1871). On irritable heart: A clinical study of a form of functional cardiac disorder and its consequences.American Journal of Medical Science 121: 17–52.
DeLuca, J., Johnson, S., and Natelson, B. (1993). Information processing effeciency in chronic fatigue syndrome and multiple sclerosis.Archives of Neurology 50: 301–304.
Fukuda, K., Straus, S., Hickie, I., Sharpe, M., Dobbins, J., Komaroff, A., and the International Chronic Fatigue Syndrome Study Group. (1994). The chronic fatigue syndrome: A comprehensive approach to its definition and study.Annals of Internal Medicine 121: 953–959.
Gold, D., Bowden, R., Sixbey, J., Riggs, R., Katon, W., Ashley, R., Obrigewitch, R., and Corey, L. (1990). Chronic fatigue: A prospective clinical and virological study.Journal of the American Medical Association 264: 48–53.
Grafman, J., Schwartz, V., Dale, J., Scheffers, M., Houser, C., and Straus, S. (1993). Analysis of neuropsychological functioning in patients with chronic fatigue syndrome.Journal of Neurology, Neurosurgery, and Psychiatry 56: 684–689.
Greenwood, R. (1987). Residual mental disorders after herpesvirus infection. In Kurstak, E., Lipowski, Z., and Morozov, P. (eds.),Viruses, Immunity, and Mental Disorders, Plenum, New York, pp. 65–80.
Holmes, F., Kaplan, J., Gantz, N., Komaroff, A., Schonberger, L., Straus, S., Jones, J., Dubois, R., Cunningham-Rundels, C., Pahwa, S., Tosato, G., Zegans, L., Purtilo, D., Brown, N., Schooley, R., and Brus, I. (1988). Chronic fatigue syndrome: A working case definition.Annals of Internal Medicine 108: 387–389.
Ichise, M., Salit, I., and Abbey, S. (1992). Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.Nuclear Medicine Communication 13: 767–772.
Johnson, S., DeLuca, J., Fielder, N., and Natelson, B. (1994). Cognitive function of patients with chronic fatigue syndrome.Clinical Infectious Diseases 18(Suppl.): s84-s85.
Kane, R. L. (1991). Standardized and flexible batteries in neuropsychology: An assessment update.Neuropsychology Review 2: 281–339.
Kane, R., Gantz, N., and DiPino, R. (1994). Neuropsychological and psychological functioning in chronic fatigue syndrome. Poster presented at the meeting of the National Academy of Neuropsychology, Orlando, FL.
Kruesi, M., Dale, J., and Straus, S. E. (1989). Psychiatric diagnoses in patients who have chronic fatigue syndrome.Journal of Clinical Psychiatry 50(2): 53–56.
Krupp, L., Sliwinski, M., Masur, D., Friedberg, F., and Coyle, P. (1994). Cognitive functioning and depression in patients with chronic fatigue syndrome and multiple sclerosis.Achieves of Neurology 51: 705–710
Manu, P., Lane, T., and Matthews, D. (1988). The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue.Annals of Internal Medicine 109: 554–556.
Manu, P., Matthews, D., and Lane, T. (1988). The mental health of patients with a chief complaint of chronic fatigue: A prospective evaluation and follow-up.Archives of Internal Medicine 148: 2213–2217.
Martin, L., and Rees, L. (1966). Reaction times and somatic reactivity in depressed patients.Journal of Psychosomatic Research 9: 375–382.
Matthews, D., Lane, T., and Manu, P. (1991). Antibodies to Epstein-Barr virus in patients with chronic fatigue.Southern Medical Journal 84(7): 832–840.
McDonald, E., Cope, H., and David, A. (1993). Cognitive impairment in patients with chronic fatigue: A preliminary study.Journal of Neurology, Neurosurgery, and Psychiatry 56: 812–815.
Mena, I. (1992). Study of cerebral perfusion by neurospect in patients with chronic fatigue syndrome. In Hyde, B., Goldstein, J., and Levine, P. (eds.),The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, The Nightingale Research Foundation, Ottawa, pp. 432–438.
Millon, C., Salvato, F., and Blaney, N. (1989). A psychological assessment of chronic fatigue syndrome/chronic Epstein-Barr virus patients.Psychological Health 3: 131–141.
Pepper, C., Krupp, L., Friedberg, F., and Doscher, C. (1993). A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression.Journal of Neuropsychiatry and Clinical Neurosciences 5(2): 200–205.
Prasher, D., Smith, A., and Findley, L. (1990). Sensory and cognitive event-related potentials in myalgic encephalomyelitis.Journal of Neurology, Neurosurgery, and Psychiatry 53: 247–253.
Price, R., North, C., Wessely, S., and Fraser, V. (1992). Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community.Public Health Reports 107(5): 514–522.
Ray, C. (1991). Chronic fatigue syndrome and depression: Conceptual and methodological ambiguities.Psychological Medicine, 21: 1–9.
Ray, C., Weir, W., Cullen, S., and Phillips, S. (1992). Illness perception and symptom components in chronic fatigue syndrome.Journal of Psychosomatic Medicine, 36(3): 243–256.
Riccio, M., Thompson, B., Wilson, B., Morgan, D., and Lant, A. (1992). Neuropsychological and psychiatric abnormalities in myalgic encephalomyelitis: A preliminary report.British Journal of Clinical Psychology 31: 111–120.
Rodin, G., and Voshart, K. (1986). Depression in the medically ill: An overview.American Journal of Psychiatry 143: 696–705.
Roy-Byrne, P., Weingartner, H., Bierer, L., Thompson, K., and Post, R. (1986). Effortful and automatic cognitive processes in depression.Archives of General Psychiatry 43: 265–267.
Sandman, C., Barron, J., Nackoul, K., Goldstein, J., and Fidler, F. (1993). Memory deficits associated with chronic fatigue immune dysfunction syndrome.Biological Psychiatry 33: 618–623.
Scheffers, M., Johnson, R., Grafman, J., Dale, J., and Straus, S. (1992). Attention and short-term memory in chronic fatigue syndrome patients: An event-related potential analysis.Neurology 42(9): 1667–1675.
Schmaling, K., DiClementi, J., Cullum, M., and Jones, J. (1994). Cognitive functioning in chronic fatigue syndrome and depression: A preliminary comparison.Psychosomatic Medicine 56: 383–388.
Straus, S. (1991). History of chronic fatigue syndrome.Review of Infectious Diseases 13(Suppl. 1): S2-S7.
Taerk, G., Toner, B., Salit, I., Garfinkle, P., and Ozersky, S. (1987). Depression in patients with neuromyasthenia (benign myalgic encephalomyelitis).International Journal of Psychiatry in Medicine 17(1): 49–56.
Wessely, S. (1993). The neuropsychiatry of chronic fatigue syndrome.Chronic Fatigue Syndrome. Ciba Foundation Symposium 173, Chichester, Wiley, pp. 212–237.
Wessely, S., and Powell, R. (1989). Fatigue syndromes: A comparison of chronic “Postviral” fatigue with neuromuscular and affective disorders.Journal of Neurology, Neurosurgery, and Psychiatry 42: 940–948.
Yeomans, J., and Conway, S. (1991). Biopsychosocial aspects of chronic fatigue syndrome (myalgic encephalomyelitis).Journal of Infection 232: 263–269.
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DiPino, R.K., Kane, R.L. Neurocognitive functioning in chronic fatigue syndrome. Neuropsychol Rev 6, 47–60 (1996). https://doi.org/10.1007/BF01875419
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DOI: https://doi.org/10.1007/BF01875419