Continuous and intermittent levodopa differentially affect rotation induced by D-1 and D-2 dopamine agonists
References (16)
- et al.
Evidence that striatal efferents relate to different dopamine receptors
Brain Res.
(1984) - et al.
Chronic amphetamine alters D-2 but not D-1 agonist-induced behavioral responces in rats
Life Sci.
(1988) - et al.
Enhanced stereotypies after repeated injections but not continuous amphetamines
Neuropharmacology
(1978) - et al.
Differential effect of repeated treatment with L-DOPA on dopamine-D-1 or D-2 receptors
Neuropharmacology
(1986) Intermittent versus continuous stimulation: effect of time interval on the development of sensitization or tolerance
Life Sci.
(1980)- et al.
Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK&F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats
Psychopharmacology
(1985) - et al.
Dopaminergic neurons: effects of antipsychotic drugs and amphetamine on single cell activity
J. Pharmacol. Exp. Ther.
(1973) - et al.
Increased or decreased locomotor response in rats following repeated administration of apomorphine depends on dosage interval
Psychopharmacology
(1985)
Cited by (147)
Safinamide in neurological disorders and beyond: Evidence from preclinical and clinical studies
2021, Brain Research BulletinCitation Excerpt :In rats, stereotactic injection of 6-OHDA in the nigrostriatal region causes degeneration of dopaminergic neurons and induction of PD via oxidative stress and mitochondrial respiratory chain arrest (Duty and Jenner, 2011). In addition, to induce levodopa induced dyskinesia or ‘wearing off’ effects, MPTP model in primates and 6-OHDA model in rats are used (Duty and Brotchie, 1997; Engber et al., 1989; Johnston and Fox, 2014). In MPTP treated C57BL/6 mice, safinamide (20 mg/kg, i.p.) when co-administrated with levodopa and benserazide, increased the brain dopamine level by 60 % (Caccia et al., 2006).
Banana (Musa spp) from peel to pulp: Ethnopharmacology, source of bioactive compounds and its relevance for human health
2015, Journal of EthnopharmacologyCitation Excerpt :According to Obeso et al. (2000), a constant firing rate of CNS dopamine neurons, stable striatal dopamine concentration, and the continuos activation of striatal dopamine receptors are essential for normal basal-ganglia function (Bédard et al., 1986; Grondin et al., 1996; Jenner, 2000). Engber et al. (1989), Juncos et al. (1989), Morissette et al. (1997), and Pavon et al. (2006) findings demonstrated that standard doses of levodopa are unable to restore basal-ganglia physiological activity to normal, because non-physiological discontinuous or pulsatile dopamine replacement induces disruption in the dopamine-denervated basal ganglia leading to the development of motor complications and dyskinesia characteristic from PD. Also disease severity can influence the risk that a drug will induce pulsatile stimulation and motor complications (Bédard et al., 1986; Pearce et al., 1998).
Controlled iontophoretic delivery of pramipexole: Electrotransport kinetics in vitro and in vivo
2014, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :It is available in the form of immediate release and extended release tablets with dose typically initiated at 0.25 mg and gradually titrated to 1.5 mg thrice daily for the immediate release formulation. The majority of the side effects associated with PD therapy have been attributed to pulsatile stimulation of the dopamine receptors [8,9]. Transdermal administration with a steady zero-order drug input eliminates peak-trough variations and enables continuous stimulation of dopamine receptors – mimicking normal physiological conditions in healthy individuals – and so reduces these complications [10,11].
The development of the rotigotine transdermal patch. A historical perspective
2013, Neurologic ClinicsDopamine receptor agonists in the treatment of advanced Parkinson's disease
2009, Parkinsonism and Related Disorders