Research articleOnuf's nucleus is frequently involved in motor neuron disease/amyotrophic lateral sclerosis
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Cited by (23)
Assessment of sympathetic sudomotor function in amyotrophic lateral sclerosis with electrochemical skin conductance
2021, Clinical NeurophysiologyCitation Excerpt :Autonomic involvement in ALS is generally mild or subclinical, and may include cardiovascular, sudomotor, gastrointestinal and urinary function (Baltadzhieva et al., 2005; Piccione et al., 2015). Several post-mortem studies in ALS have shown degenerative changes in the intermediolateral column neurons (Kennedy and Duchen, 1985), Onuf nucleus (Bergmann et al., 1995; Kihira et al., 1997) and hypothalamic pathways (Vercruysse et al., 2018). Autonomic dysfunction with impairment of cardiovascular control has been documented, particularly in advanced stages of the disease, and during sleep (Asai et al., 2007; Congiu et al., 2019; Pavlovic et al., 2010; Pinto et al., 2012), possibly related to sudden death during sleep (Asai et al., 2007; Pinto et al., 2012; Congiu et al., 2019).
No relation between sympathetic outflow to muscles and respiratory function in amyotrophic lateral sclerosis
2015, Journal of the Neurological SciencesCitation Excerpt :Asai et al. reported that there was a significant inverse correlation between the QTc interval on electrocardiography and the number of intermediolateral nucleus sympathetic neurons in the spinal cord, and that sudden cardiac arrest was common in patients with QTc prolongation [28]. So far, there have been few neuropathological studies on the autonomic nervous system performed in ALS [24,29]. Further investigation of the neuropathological findings and autonomic dysfunction in patients with ALS is needed to clarify the importance of autonomic dysfunction in this disease.
Cell-autonomous and non-cell-autonomous toxicity in polyglutamine diseases
2012, Progress in NeurobiologyCitation Excerpt :It is noteworthy that, although the motor neurons that form Onuf's nucleus express high levels of AR, these cells are spared in SBMA (Rusmini et al., 2010; Sobue, 1995). Interestingly, cytoskeletal and morphological abnormalities in the absence of motor neuron loss have been reported in Onuf's nucleus in amyotrophic lateral sclerosis, indicating that these motor neurons are vulnerable to the accumulation of toxic proteins (Bergmann et al., 1995; Kihira et al., 1997; Okamoto et al., 1991). It remains to be established whether similar changes are present in Onuf's nucleus in SBMA patients.
Can vitamin D delay the progression of ALS?
2011, Medical HypothesesCitation Excerpt :Similarly, vitamin D may potentiate axone regeneration in patients with ALS. Some motor neurons such as Onuf’s nucleus motor neurons, oculomotor, trochlear, and abducens nerve neurons are less prone to motor neuron degeneration in patients with ALS [7]. This is probably related to the high level of calcium binding proteins (CBPs) in those resistant cells which appears to protect them from the pathological process [8–11].
Involvement of Onuf's nucleus in amyotrophic lateral sclerosis
1997, Journal of the Neurological SciencesNon-motor symptoms in amyotrophic lateral sclerosis: lessons from Parkinson’s disease
2023, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration