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Nutrition and Bipolar Depression
2016, Psychiatric Clinics of North AmericaCitation Excerpt :However, evidence for its use in bipolar disorder is limited. Only one published study assessed the use of folic acid augmentation (200 μg) versus placebo in a small sample of bipolar depressed patients treated with lithium.73 No significant difference was observed between the 2 groups in their depressive symptoms after 52 weeks.
Treatment of Bipolar Depression: Evolving Recommendations
2016, Psychiatric Clinics of North AmericaFolates and aging: Role in mild cognitive impairment, dementia and depression
2015, Ageing Research ReviewsCitation Excerpt :It is notable that in the report by de Jager et al., cognitive decline was prevented only in subjects with a high baseline homocysteine level. Moreover, in middle-aged and older depressed patients, especially those with folate deficiency, folic acid or 5-MTHF supplementation has been shown to improve mood/depressive symptoms, short-term memory and social recovery (Coppen et al., 1986; Godfrey et al., 1990; Passeri et al., 1993; Reynolds, 2006). Interestingly, the combined administration of folate supplements plus antidepressants or cholinesterase inhibitors (the first line treatment for AD) to patients with depression (Almeida et al., 2014; Coppen and Bailey, 2000) or AD (Connelly et al., 2008), respectively, improved their response to those drugs compared with patients receiving the drug only.
Psychotropic drugs
2015, Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment: Third EditionSingle-Micronutrient and Broad-Spectrum Micronutrient Approaches for Treating Mood Disorders in Youth and Adults
2014, Child and Adolescent Psychiatric Clinics of North AmericaThe neurology of folic acid deficiency
2014, Handbook of Clinical NeurologyCitation Excerpt :In patients with depression the presence of folate deficiency is associated with a poorer response to standard antidepressant therapy (Reynolds et al., 1970; Papakostas et al., 2005). Six controlled trials for periods varying from 8 weeks to 1 year have confirmed an effect of folates on mood and social recovery either directly or mostly in addition to psychotropic treatment in psychiatric patients mainly with depression (Botez et al., 1979b; Coppen et al., 1986; Godfrey et al., 1990; Passeri et al., 1993; Coppen and Bailey, 2000; Papakostas et al., 2012). The details of the trials and outcomes are summarized in Table 61.2.