Elsevier

Neuroscience Letters

Volume 106, Issues 1–2, 20 November 1989, Pages 49-54
Neuroscience Letters

Lewy bodies in tyrosine hydroxylase-synthesizing neurons of the human cerebral cortex

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Abstract

A population of neurons situated in the human cerebral neocortex contains mRNA coding for tyrosine hydroxylase, the key enzyme for catecholamine biosynthesis. Phosphorylated neurofilament-containing cytoplasmic inclusions occur in these neurons in diffuse Lewy body disease, indicating a tendency for selective involvement that is shared with subcortical catecholamine-containing neurons. These findings are relevant to the pathophysiology of several neurologic and psychiatric illnesses in which the monoamine-containing neurons of the neocortex may participate.

Keywords

Tyrosine hydroxylase
Cerebral cortex
Lewy body
Dementia
Parkinson's disease
Schizophrenia
Affective disorder
Catecholamine

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Present address: Department of Biochemistry and Molecular Biology, Universidad de la Laguna, Santa Cruz de Tenerife, Spain.