Main articleGenerator sites for spontaneous activity in neuromyotonia. An EMG study
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Cited by (39)
Demystifying the spontaneous phenomena of motor hyperexcitability
2021, Clinical NeurophysiologyCitation Excerpt :Some authors have advocated a less clear distinction between the intra-burst frequency ranges found in myokymic discharges and neuromyotonic discharges, promoting the concept that these phenomena lie on a pathophysiological spectrum (Daube, 2001, Maddison, 2006). Neuromyotonic discharges can be initiated by voluntary effort, movement of the needle during EMG examination, percussion of the nerve and/or electrical stimulation (Bednarĺk and Kadanka, 2001, Torbergsen et al., 1996). The amplitude of the discharges typically wanes during a single burst (Gutmann and Libell, 2001).
Standards for quantification of EMG and neurography
2019, Clinical NeurophysiologyThe generator site in acquired autoimmune neuromyotonia
2017, Clinical NeurophysiologyCitation Excerpt :Thus both proximal and more distal depolarization sites were active in our patients. In previous reports it has been suggested that neuromyotonic discharges are mostly generated at ectopic sites either proximally (Torbergsen et al., 1996) or distally (Arimura et al., 2005). Curiously, these two not mutually exclusive concepts were derived by investigators both using the MacroEMG recording method, including the developer of the technique.
Fasciculation discharge frequency in amyotrophic lateral sclerosis and related disorders
2016, Clinical NeurophysiologyCitation Excerpt :We attribute the rarity of FPs in this disorder to the relative absence of peripheral motor axonal sprouting. ALS has been associated with abnormal sodium and slow potassium channel activity in motor axons (Bostock et al., 1995), but this has not been specifically associated with focal sites of FP generation, unlike neuromyotonia, a disorder in which there are multiple focal zones of increased excitability in motor nerve fibres (Torberg et al., 1996). In ALS it has proved difficult to determine the precise localisation of sites of ectopic activity leading to FP generation, and both central and peripheral sites of origin have been suggested (de Carvalho and Swash, 1998, 2012; Hirota et al., 2000).
Chapter 14 Peripheral nerve hyperexcitability and the neuromuscular junction
2008, Handbook of Clinical NeurologyCitation Excerpt :Electromyographic studies reveal that the shape of successive single or grouped fasciculations often varies. This variability suggests that the spontaneous discharge originates within single motor nerve terminals and then propagates to the entire motor unit by an axon reflex (Layzer, 1994; Torbergsen et al., 1996). Many acquired cases of generalized PNH appear to have an autoimmune basis.
Neuromyotonia
2006, Clinical Neurophysiology
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Present address: Vestfold County Hospital, Tönsberg, Norway.