Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels

Neuroradiology. 1999 Sep;41(9):650-3. doi: 10.1007/s002340050818.

Abstract

Oligodendroglial gliomatosis cerebri is very rare. We describe 42-year-old woman who had low-grade oligodendroglial gliomatosis cerebri confirmed on stereotactic biopsy. The diffuse nature of the tumour was apparent clinically, neurophysiologically, on MRI and on proton magnetic resonance spectroscopy (MRS). She also had an isolated, false-localising partial seventh nerve palsy. MRS, of which there are no previous reports, suggested elevated glycine/inositol levels. This might be explained by the cell lineage from which the tumour arose.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Biopsy, Needle
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / pathology*
  • Glycine / metabolism*
  • Humans
  • Inositol / metabolism*
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy*
  • Oligodendroglia / pathology
  • Oligodendroglioma / diagnosis
  • Oligodendroglioma / pathology*
  • Stereotaxic Techniques
  • Temporal Lobe / pathology

Substances

  • Aspartic Acid
  • Inositol
  • N-acetylaspartate
  • Glycine