Neuropsychiatric disturbances in Parkinson's disease clusters in five groups with different prevalence of dementia

Acta Psychiatr Scand. 2005 Sep;112(3):201-7. doi: 10.1111/j.1600-0447.2005.00562.x.

Abstract

Objective: To investigate the inter-relationship of neuropsychiatric disturbances in Parkinson's disease (PD) by cluster analysis and describe the properties of the clusters.

Method: A total of 139 patients were assessed using the neuropsychiatric inventory (NPI). A cluster-analysis was used to investigate the inter-relationship of NPI items. The clusters were profiled regarding dementia (PDD) and major depression.

Results: A total of 39 patients showed no neuropsychiatric symptoms. The remaining 100 patients (43% PDD) were divided in to five clusters. The largest group (42, 31% PDD) showed symptoms of mild depression, followed by a group (29, 79.3% PDD) with hallucinations and mild other symptoms. The third group (14, 7.1% PDD) had sleep disturbances exclusively. The fourth group (8, 25% PDD) showed apathy, anxiety and depression. The smallest group (7, 57.1% PDD) had high scores on several NPI items.

Conclusion: Our PD sample can be divided in to clusters based on the NPI, with different prevalence of dementia and depression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cluster Analysis
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / epidemiology*
  • Dementia / diagnosis*
  • Dementia / epidemiology*
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Mental Disorders / diagnosis*
  • Mental Disorders / etiology*
  • Middle Aged
  • Neuropsychological Tests*
  • Parkinson Disease / epidemiology*
  • Prevalence
  • Psychiatry / methods*
  • Surveys and Questionnaires