Serotonin transporter gene promoter region polymorphism associated with poststroke major depression

J Neuropsychiatry Clin Neurosci. 2006 Winter;18(1):96-9. doi: 10.1176/jnp.18.1.96.

Abstract

The authors examined variations of serotonin transporter-linked promoter region (5-HTTLPR) functional polymorphism in 26 stroke patients with major depression and in 25 unrelated nondepressed stroke subjects of Caucasian descent. Findings indicate a significant association between 5-HTTLPR short variant genotype and poststroke major depression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Depressive Disorder, Major / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics*
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Statistics as Topic
  • Stroke / genetics*

Substances

  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins