Cerebral amyloid angiopathy (CAA) is defined by the accumulation of amyloid in the walls of small-and medium-sized cerebral arteries. One of the most recognized complications of CAA is spontaneous, often recurrent, intracerebral hemorrhage, usually involving the cortex and/or subcortical white matter ("lobar hemorrhage"). Several useful animal and in vitro models as well as specific neuroimaging techniques have been recently developed, which are expected to provide detailed insight into the pathogenesis of CAA and contribute to the development of targeted antiamyloid therapies.