The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

Mov Disord. 2009 Aug 15;24(11):1641-9. doi: 10.1002/mds.22643.

Abstract

We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0-32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ-39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antiparkinson Agents / therapeutic use
  • Anxiety / epidemiology
  • Anxiety / etiology
  • Anxiety / psychology
  • Cognition Disorders / epidemiology
  • Cognition Disorders / etiology
  • Cognition Disorders / psychology
  • Depression / epidemiology
  • Depression / etiology
  • Depression / psychology
  • Fatigue / epidemiology
  • Fatigue / etiology
  • Fatigue / psychology
  • Female
  • Gastrointestinal Diseases / epidemiology
  • Gastrointestinal Diseases / etiology
  • Gastrointestinal Diseases / psychology
  • Humans
  • Italy / epidemiology
  • Male
  • Middle Aged
  • Olfaction Disorders / epidemiology
  • Olfaction Disorders / etiology
  • Olfaction Disorders / psychology
  • Pain / epidemiology
  • Pain / etiology
  • Pain / psychology
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy
  • Parkinson Disease / psychology*
  • Quality of Life*
  • Sleep Disorders, Intrinsic / epidemiology
  • Sleep Disorders, Intrinsic / etiology
  • Sleep Disorders, Intrinsic / psychology
  • Urination Disorders / epidemiology
  • Urination Disorders / etiology
  • Urination Disorders / psychology

Substances

  • Antiparkinson Agents