Abstract
Abnormal eye movements are increasingly recognised in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, key points with illustrative case histories and eye movement records are highlighted.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Aged
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Amyotrophic Lateral Sclerosis / complications
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Amyotrophic Lateral Sclerosis / diagnosis
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Amyotrophic Lateral Sclerosis / physiopathology*
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Disease Progression
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Eye Movements / physiology*
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Fixation, Ocular / physiology
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Humans
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Male
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Nystagmus, Pathologic / etiology
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Ocular Motility Disorders / diagnosis
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Ocular Motility Disorders / etiology*
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Ocular Motility Disorders / physiopathology
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Ophthalmoplegia / etiology
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Saccades
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Supranuclear Palsy, Progressive / physiopathology