This pilot study tests one model for interdisciplinary research between speech science and psychiatry. Strengths and weaknesses of the model are noted. Thirteen depressed subjects were evaluated before and after treatment with antidepressant medication. Subjects were rated on scales for severity of depression and speech deviations. Scores on a depressed voice scale, comprising seven of the speech dimensions found to be most consistently altered in depression, showed significant improvement after treatment for depression. The constellation of speech signs found in depression suggested a hypokinetic disturbance of the extrapyramidal system. Several directions for further inquiry into this potential relationship are suggested.