Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes

R M Beatty; A A Sadun; L Smith; J P Vonsattel; E P Richardson Jr

doi:10.1136/jnnp.45.2.143

Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes

J Neurol Neurosurg Psychiatry. 1982 Feb;45(2):143-6. doi: 10.1136/jnnp.45.2.143.

Authors

R M Beatty, A A Sadun, L Smith, J P Vonsattel, E P Richardson Jr

Abstract

Transneuronal degeneration of retinal ganglion cells was directly demonstrated in a patient who had unilateral removal of the striate cortex forty years prior to necropsy. For comparison, another case is presented showing anterograde transneuronal atrophy forty years after enucleation of one eye.

Publication types

Case Reports

MeSH terms

Aged
Dominance, Cerebral / physiology
Geniculate Bodies / anatomy & histology
Humans
Male
Nerve Degeneration*
Nerve Fibers, Myelinated / ultrastructure
Optic Chiasm / anatomy & histology
Optic Nerve / anatomy & histology
Retina / anatomy & histology*
Sensory Deprivation / physiology*
Synapses / ultrastructure*
Visual Cortex / anatomy & histology*
Visual Pathways / anatomy & histology