Abstract
Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Basal Ganglia / anatomy & histology
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Basal Ganglia / physiopathology
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Basal Ganglia / surgery*
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Dopamine / physiology
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Female
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Globus Pallidus / physiopathology
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Haplorhini
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Male
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Neural Pathways
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Parkinson Disease / physiopathology
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Parkinson Disease / surgery*
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Receptors, Glutamate / physiology
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Stereotaxic Techniques*
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Thalamic Nuclei / physiopathology
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Thalamic Nuclei / surgery*
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gamma-Aminobutyric Acid / physiology
Substances
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Receptors, Glutamate
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gamma-Aminobutyric Acid
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Dopamine