Vigabatrin and depression

J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):925-8. doi: 10.1136/jnnp.56.8.925.

Abstract

Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in their seizure frequency. Most patients had a history of affective disturbance, sometimes in association with other GABAergic drugs. The observations support a possible role for GABAergic mechanisms in the biology of mood disorders.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aminocaproates / adverse effects*
  • Aminocaproates / therapeutic use
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Depressive Disorder / chemically induced*
  • Depressive Disorder / psychology
  • Epilepsies, Partial / drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Vigabatrin

Substances

  • Aminocaproates
  • Anticonvulsants
  • Vigabatrin