Systemic histiocytosis presenting as multiple sclerosis

M E Smith; D A Katz; J O Harris; J A Frank; C V Kufta; D E McFarlin

doi:10.1002/ana.410330521

Systemic histiocytosis presenting as multiple sclerosis

Ann Neurol. 1993 May;33(5):549-54. doi: 10.1002/ana.410330521.

Authors

M E Smith¹, D A Katz, J O Harris, J A Frank, C V Kufta, D E McFarlin

Affiliation

¹ Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892.

PMID: 8498832
DOI: 10.1002/ana.410330521

Abstract

A patient resembling one with progressive multiple sclerosis in clinical presentation and by magnetic resonance imaging was studied in detail. Some features atypical for multiple sclerosis prompted a persistent search for an alternative cause. The diagnosis of a non-Langerhans systemic histiocytosis involving brain and bone was established and showed a partial response to radiation therapy. This patient illustrates the continued importance of a broad approach to the evaluation of possible multiple sclerosis, with particular attention to atypical features.

Publication types

Case Reports

MeSH terms

Biopsy
Bone and Bones / diagnostic imaging
Bone and Bones / pathology
Brain / pathology
Brain Diseases / diagnosis*
Brain Diseases / pathology
Brain Diseases / radiotherapy
Diagnosis, Differential
Follow-Up Studies
Glial Fibrillary Acidic Protein / analysis
Histiocytes / pathology
Histiocytosis / diagnosis*
Histiocytosis / pathology
Histiocytosis / radiotherapy
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / diagnosis*
Radiography
Radionuclide Imaging

Substances

Glial Fibrillary Acidic Protein