Long-term results with cisapride in Parkinson's disease

Mov Disord. 1997 May;12(3):423-5. doi: 10.1002/mds.870120324.

Abstract

In this study, we examined whether there is a long-term effect of cisapride on colonic transit in Parkinson's disease. Twenty-five patients (11 women, 14 men; average age, 64.4 years; moderate symptoms) were studied and treated initially with cisapride, 5 mg, twice a day, and after the first week with cisapride, 10 mg, twice a day. Colonic transit was measured by radioopaque markers at various stages: after 1 week, 6 months, and 1 year. In untreated patients, transit took 131 h; after 1 week with cisapride, it was accelerated to 81 h. After 6 months, colonic transit time amounted to 99 and 118 h, respectively, after 1 year. Cisapride seems to be highly effective initially. After 6 months, a significant but reduced effect was seen, and after 1 year, only a small effect could be demonstrated.

MeSH terms

  • Aged
  • Cathartics / administration & dosage
  • Cathartics / therapeutic use*
  • Cisapride
  • Constipation / complications
  • Constipation / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / complications*
  • Peristalsis / drug effects
  • Piperidines / administration & dosage
  • Piperidines / pharmacology
  • Piperidines / therapeutic use*
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Cathartics
  • Piperidines
  • Cisapride