PT  - JOURNAL ARTICLE
AU  - P M Satchell
AU  - J G McLeod
AU  - B Harper
AU  - A H Goodman
TI  - Abnormalities in the vagus nerve in canine acrylamide neuropathy.
AID  - 10.1136/jnnp.45.7.609
DP  - 1982 Jul 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 609--619
VI  - 45
IP  - 7
4099  - http://jnnp.bmj.com/content/45/7/609.short
4100  - http://jnnp.bmj.com/content/45/7/609.full
SO  - J Neurol Neurosurg Psychiatry1982 Jul 01; 45
AB  - Dogs exposed to acrylamide develop a sensorimotor peripheral neuropathy and megaoesophagus. The presence of neuropathy was confirmed electrophysiologically and histologically. Hindlimb motor conduction velocity was reduced and there was a loss of large diameter myelinated fibres in the dorsal common digital nerve and the tibial nerve. The conduction velocity of vagal motor fibres innervating the thoracic oesophagus was not decreased; there was a reduction in the conduction velocity of the mixed nerve action potential of the vagus. Degenerating nerve fibres were observed in the vagus in the midthoracic region. The damage to vagal nerve fibres may be an important factor in the causation of megaoesophagus.