PT  - JOURNAL ARTICLE
AU  - G Lennox
AU  - J Lowe
AU  - M Landon
AU  - E J Byrne
AU  - R J Mayer
AU  - R B Godwin-Austen
TI  - Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.
AID  - 10.1136/jnnp.52.11.1236
DP  - 1989 Nov 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 1236--1247
VI  - 52
IP  - 11
4099  - http://jnnp.bmj.com/content/52/11/1236.short
4100  - http://jnnp.bmj.com/content/52/11/1236.full
SO  - J Neurol Neurosurg Psychiatry1989 Nov 01; 52
AB  - Diffuse Lewy body disease is an important pathological substrate of the common syndrome of parkinsonian dementia. The new technique of anti-ubiquitin immunocytochemistry has been used in a correlative quantitative neuropathological study of fifteen cases of diffuse Lewy body disease, showing that the severity of dementia is related to cortical Lewy body density, whilst subcortical abnormalities make a much less significant contribution. Cortical senile plaques also appear to be part of the pathology of diffuse Lewy body disease and should not therefore be used as an isolated diagnostic criterion for Alzheimer's disease. Diagnostic criteria for diffuse Lewy body disease are discussed.