PT  - JOURNAL ARTICLE
AU  - U C Wieshmann
AU  - M R Symms
AU  - G J M Parker
AU  - C A Clark
AU  - L Lemieux
AU  - G J Barker
AU  - S D Shorvon
TI  - Diffusion tensor imaging demonstrates deviation of fibres in normal appearing white matter adjacent to a brain tumour
AID  - 10.1136/jnnp.68.4.501
DP  - 2000 Apr 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 501--503
VI  - 68
IP  - 4
4099  - http://jnnp.bmj.com/content/68/4/501.short
4100  - http://jnnp.bmj.com/content/68/4/501.full
SO  - J Neurol Neurosurg Psychiatry2000 Apr 01; 68
AB  - the objective was to study fibre orientation in the cerebral white matter of a patient with a brain tumour using diffusion tensor imaging (DTI).  A patient with a mild left hemiparesis and a tumour in the right frontal lobe and 20 healthy volunteers were scanned with a DTI sequence. The scans were spatially normalised and the fibre orientation in the patient compared with the fibre orientation in normal controls.  DTI disclosed a change of the orientation of fibres in the patient compared with normal controls. In the normal appearing white matter adjacent to the tumour fibres deviated from the normal superior inferior orientation in the corona radiata by about 30o. This finding was consistent with a displacement by distant mass effect rather than a destruction of fibres, in agreement with the neurological examination.  In conclusion, DTI demonstrated a deviation of fibres in normal appearing white matter adjacent to a tumour. The technique will improve understanding of the effects of structural abnormalities on fibres. This will assist the interpretation of clinical findings and functional imaging studies and guide neurosurgical interventions.