RT Journal Article
SR Electronic
T1 Treatment of stiff person syndrome with rituximab
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 999
OP 1001
DO 10.1136/jnnp.2004.051144
VO 76
IS 7
A1 M R Baker
A1 M Das
A1 J Isaacs
A1 P R W Fawcett
A1 D Bates
YR 2005
UL http://jnnp.bmj.com/content/76/7/999.abstract
AB This case report is about the novel use of the anti-CD20 antibody, rituximab, in the treatment of a 41 year old woman with stiff person syndrome. She was admitted to hospital as an emergency with prolonged and painful extensor spasms affecting the neck and back, arms, and legs. The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunoglobulin and cytotoxics. Treatment with rituximab induced a lasting clinical remission.