TY - JOUR T1 - Disrupted small world topology and modular organisation of functional networks in late-life depression with and without amnestic mild cognitive impairment JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1097 LP - 1105 DO - 10.1136/jnnp-2014-309180 VL - 86 IS - 10 AU - Wenjun Li AU - B Douglas Ward AU - Xiaolin Liu AU - Gang Chen AU - Jennifer L Jones AU - Piero G Antuono AU - Shi-Jiang Li AU - Joseph S Goveas Y1 - 2015/10/01 UR - http://jnnp.bmj.com/content/86/10/1097.abstract N2 - Background The topological architecture of the whole-brain functional networks in those with and without late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are unknown.Aims To investigate the differences in the small-world measures and the modular community structure of the functional networks between patients with LLD and aMCI when occurring alone or in combination and cognitively healthy non-depressed controls.Methods 79 elderly participants (LLD (n=23), aMCI (n=18), comorbid LLD and aMCI (n=13), and controls (n=25)) completed neuropsychiatric assessments. Graph theoretical methods were employed on resting-state functional connectivity MRI data.Results LLD and aMCI comorbidity was associated with the greatest disruptions in functional integration measures (decreased global efficiency and increased path length); both LLD groups showed abnormal functional segregation (reduced local efficiency). The modular network organisation was most variable in the comorbid group, followed by patients with LLD-only. Decreased mean global, local and nodal efficiency metrics were associated with greater depressive symptom severity but not memory performance.Conclusions Considering the whole brain as a complex network may provide unique insights on the neurobiological underpinnings of LLD with and without cognitive impairment. ER -