RT Journal Article
SR Electronic
T1 Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 70
OP 75
DO 10.1136/jnnp-2016-314414
VO 88
IS 1
A1 Candice Delcourt
A1 Danni Zheng
A1 Xiaoying Chen
A1 Maree Hackett
A1 Hisatomi Arima
A1 Jun Hata
A1 Emma Heeley
A1 Rustam Al-Shahi Salman
A1 Mark Woodward
A1 Yining Huang
A1 Thompson Robinson
A1 Pablo M Lavados
A1 Richard I Lindley
A1 Christian Stapf
A1 Leo Davies
A1 John Chalmers
A1 Craig S Anderson
A1 Shoichiro Sato
YR 2017
UL http://jnnp.bmj.com/content/88/1/70.abstract
AB Background and purpose Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2).Methods The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150–220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL.Results 2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively.Conclusions Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score.Trial registration numbers NCT00226096 and NCT00716079; Post-results.