RT Journal Article SR Electronic T1 Neuroendocrine abnormalities in Parkinson's disease JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 176 OP 185 DO 10.1136/jnnp-2016-314601 VO 88 IS 2 A1 Eduardo De Pablo-Fernández A1 David P Breen A1 Pierre M Bouloux A1 Roger A Barker A1 Thomas Foltynie A1 Thomas T Warner YR 2017 UL http://jnnp.bmj.com/content/88/2/176.abstract AB Neuroendocrine abnormalities are common in Parkinson's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin resistance and bone metabolism, and body weight changes. They have been associated with multiple non-motor symptoms in PD and have important clinical consequences, including therapeutics. Some of the underlying mechanisms have been implicated in the pathogenesis of PD and represent promising targets for the development of disease biomarkers and neuroprotective therapies. In this systems-based review, we describe clinically relevant neuroendocrine abnormalities in Parkinson's disease to highlight their role in overall phenotype. We discuss pathophysiological mechanisms, clinical implications, and pharmacological and non-pharmacological interventions based on the current evidence. We also review recent advances in the field, focusing on the potential targets for development of neuroprotective drugs in Parkinson's disease and suggest future areas for research.