RT Journal Article SR Electronic T1 Treatment dilemmas in Guillain-Barré syndrome JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 346 OP 352 DO 10.1136/jnnp-2016-314862 VO 88 IS 4 A1 Christine Verboon A1 Pieter A van Doorn A1 Bart C Jacobs YR 2017 UL http://jnnp.bmj.com/content/88/4/346.abstract AB Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical course and outcome. Intravenous immunoglobulin (IVIg) and plasma exchange are proven effective treatments, but the efficacy has been demonstrated mainly on motor improvement in adults with a typical and severe form of GBS. In clinical practice, treatment dilemmas may occur in patients with a relatively mild presentation, variant forms of GBS, or when the onset of weakness was more than 2 weeks ago. Other therapeutic dilemmas may arise in patients who do not improve or even progress after initial treatment. We provide an overview of the current literature about therapeutic options in these situations, and additionally give our personal view that may serve as a basis for therapeutic decision-making.