RT Journal Article
SR Electronic
T1 Neuropsychiatric syndromes of multiple sclerosis
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 697
OP 708
DO 10.1136/jnnp-2016-315367
VO 88
IS 8
A1 Ruth Murphy
A1 Stefani O’Donoghue
A1 Timothy Counihan
A1 Colm McDonald
A1 Peter A Calabresi
A1 Mohammed AS Ahmed
A1 Adam Kaplin
A1 Brian Hallahan
YR 2017
UL http://jnnp.bmj.com/content/88/8/697.abstract
AB Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis (MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or more commonly with disease progression. However, the pathogenesis of these comorbid conditions remains unclear and it remains difficult to accurately elucidate if neuropsychiatric symptoms or conditions are indicators of MS illness severity. Furthermore, both the disease process and the treatments of MS can adversely impact an individual’s mental health. In this review, we discuss the common neuropsychiatric syndromes that occur in MS and describe the clinical symptoms, aetiology, neuroimaging findings and management strategies for these conditions.