TY - JOUR T1 - Pathogenesis of dystonia: is it of cerebellar or basal ganglia origin? JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry DO - 10.1136/jnnp-2017-316250 SP - jnnp-2017-316250 AU - Ryuji Kaji AU - Kailash Bhatia AU - Ann M Graybiel Y1 - 2017/10/31 UR - http://jnnp.bmj.com/content/early/2017/10/31/jnnp-2017-316250.abstract N2 - Dystonia is a disorder of motor programmes controlling semiautomatic movements or postures, with clinical features such as sensory trick, which suggests sensorimotor mismatch as the basis. Dystonia was originally classified as a basal ganglia disease. It is now regarded as a ‘network’ disorder including the cerebellum, but the exact pathogenesis being unknown. Rare autopsy studies have found pathology both in the striatum and the cerebellum, and functional disorganisation was reported in the somatosensory cortex in patients. Recent animal studies showed physiologically tight disynaptic connections between the cerebellum and the striatum. We review clinical evidence in light of this new functional interaction between the cerebellum and basal ganglia, and put forward a hypothesis that dystonia is a basal ganglia disorder that can be induced by aberrant afferent inputs from the cerebellum. ER -