Table 1

ApoE alleles in 85 year old people in relation to dementia and different diagnostic categories of dementia

		Alleles (n)		Allele frequency		Subjects (n)		OR for dementia disorders in those having at least one allele of:
		Alleles (n)		ε2	ε3	Subjects (n)		ε4	ε2 v no ε2	ε3 v no ε3	ε4 v no ε4
No dementia	606	0.112	0.670	0.218	303
Any dementia	218	0.078	0.619	0.303^1-150	109	0.7 (0.4 to 1.2)	0.9 (0.4 to 2.3)	1.9^‡ (1.2 to 2.9)
Alzheimer’s disease (AD)	104	0.067	0.625	0.308	52	0.5 (0.2 to 1.3)	1 (0.3 to 3.6)	1.9^† (1.1 to 3.5)
Mixed dementia (MIX)	20	0.100	0.400	0.500^**	10	0.9 (0.2 to 4.2)	0.1^† (0.04 to 0.6)	6.2^† (1.3 to 29.6)
Multi-infarct dementia (MID)	68	0.103	0.647	0.250	34	0.9 (0.4 to 2.2)	—	1.5 (0.8 to 3.1)
Other dementias	22	0.046	0.727	0.227	11	0.4 (0.04 to 2.8)	—	1.3 (0.4 to 4.3)
All AD (including MIX)	124	0.073	0.589	0.339^**	62	0.6 (0.3 to 1.3)	0.6 (0.2 to 1.6)	2.3^‡ (1.3 to 4.0)
All vascular dementia (MID+MIX+hypoperfusion)	92	0.098	0.587	0.315^1-150	46	0.9 (0.4 to 1.9)	0.7 (0.2 to 2.1)	2.0^† (1.1 to 3.8)

↵1-150 p < 0.05; ^** p < 0.01 v no dementia; ^† p < 0.05; ^‡ p < 0.01 v those not carrying the allele.